Mark Akeson
Department of Biomolecular Engineering
University of California
Santa Cruz, California, 95064
Tel: 831-459-1038
email: makeson@soe.ucsc.edu






TRAINING
  • Post-Doctoral Fellow in Molecular Biology. National Institutes of Health, Bethesda, Maryland. Advisor, Dr. James F. Battey, Director, National Institute on Deafness and Other Communicative Disorders. 1990-1996.
  • Ph.D., University of California, Davis, in Soil Microbiology. Advisor Dr. Donald N. Munns. 1989.
  • B.A. in 20th Century European History, Minor in Biology, Revelle College, University of California, San Diego. 1977.
KEY PUBLICATIONS IN NANOPORE TECHNOLOGY

Garalde, DR; Simon, CA; Dahl, JM; Wang, H; Akeson, M; Lieberman, KR. 2011. Distinct Complexes of DNA Polymerase I (Klenow Fragment) for Base and Sugar Discrimination during Nucleotide Substrate Selection. JOURNAL OF BIOLOGICAL CHEMISTRY 286 (16): 14480-14492.

Olasagasti, F; Lieberman, KR; Benner, S; Cherf, GM; Dahl, JM; Deamer, DW; Akeson, M. 2010. Replication of individual DNA molecules under electronic control using a protein nanopore. NATURE NANOTECHNOLOGY 5 (11): 798-806.

Hurt, N; Wang, HY; Akeson, M; Lieberman, KR. 2009. Specific Nucleotide Binding and Rebinding to Individual DNA Polymerase Complexes Captured on a Nanopore. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 131 (10): 3772-3778.

Benner, S; Chen, RJA; Wilson, NA; Abu-Shumays, R; Hurt, N; Lieberman, KR; Deamer, DW; Dunbar, WB; Akeson, M. 2007. Sequence-specific detection of individual DNA polymerase complexes in real time using a nanopore. NATURE NANOTECHNOLOGY 2 (11): 718-724.

Hornblower, B; Coombs, A; Whitaker, RD; Kolomeisky, A; Picone, SJ; Meller, A; Akeson, M. 2007. Single-molecule analysis of DNA-protein complexes using nanopores. NATURE METHODS 4 (4): 315-317.

Vercoutere, W; Winters-Hilt, S; Olsen, H; Deamer, D; Haussler, D; Akeson, M. 2001. Rapid discrimination among individual DNA hairpin molecules at single-nucleotide resolution using an ion channel. NATURE BIOTECHNOLOGY 19 (3): 248-252.

Akeson, M; Branton, D; Kasianowicz, JJ; Brandin, E; Deamer, DW. 1999. Microsecond time-scale discrimination among polycytidylic acid, polyadenylic acid, and polyuridylic acid as homopolymers or as segments within single RNA molecules. BIOPHYSICAL JOURNAL 77 (6): 3227-3233.
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